Injury and repair in the neurovascular unit
نویسندگان
چکیده
منابع مشابه
The implication of neurovascular unit signaling in controlling the subtle balance between injury and repair following ischemic stroke
Neurovascular unit (NVU): Brain microvasculature has a close structural and functional relationship with brain parenchyma, an aspect governed by the NVU (Hermann and ElAli, 2012). The concept of it was introduced by the Stroke Progress Review Group who defined it as triad of neurons, glia (astrocytes and microglia), and adjacent vasculature (arterioles and capillaries) [The Stroke Progress Revi...
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The neurovascular unit (NVU) is a dynamic structure assembled by endothelial cells (EC), a basement membrane (BM), perivascular astrocytes (PA), pericytes, and surrounding neurons. The NVU regulates the passage of substances and cellular elements from the intravascular space into the brain parenchyma. This function, also known as blood-brain barrier (BBB), is regulated by the integrity of tight...
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One of the major recommendations emerging from the NINDS Stroke Progress Review Group was to shift the emphasis from a purely neurocentric view of cell death toward a more integrative approach whereby responses in all brain cells and matrix are considered during cerebral ischemia (see Figure). The concept of the neurovascular unit (fundamentally comprising endothelium, astrocyte, and neuron) pr...
متن کاملNeurovascular Unit in Chronic Pain
Chronic pain is a debilitating condition with major socioeconomic impact, whose neurobiological basis is still not clear. An involvement of the neurovascular unit (NVU) has been recently proposed. In particular, the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), two NVU key players, may be affected during the development of chronic pain; in particular, transient permeabilizatio...
متن کاملPericyte signaling in the neurovascular unit.
Brain pericytes are intimately associated with capillary endothelial cells, separated only by basement membrane. Pericyte research has been hampered by absence of pericyte-specific immunochemical markers. The vast array of pericyte functions include contractility, immunologic, migratory, and angiogenic. Pericytes have stem cell potential, contribute to the integrity of the blood-brain barrier, ...
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ژورنال
عنوان ژورنال: Neurological Research
سال: 2012
ISSN: 0161-6412,1743-1328
DOI: 10.1179/1743132812y.0000000019